P-024: Rising incidence and increasing severity of very early onset IBD in Ireland

P03-024 – Early onset IBD treated by tocilizumab

Introduction Inflammatory bowel diseases (IBD) normally manifest in adolescent and young adults; nevertheless, in about 1% of the cases, disease onset occurs before the 1 year of age. The clinical picture is often characterized by an indeterminate colitis whose clinical remission is difficult to achieve. Current treatment for IBD consists of either immunosuppressant or biological (Infliximab, A...

Linkage of Parkinson’s disease in two very early onset siblings to a locus on chromosome 1

Parkinson’s disease (PD) is a prevalent neurodegenerative disease that usually affects individuals over 50 years of age. Age at onset in a small subset of PD cases is considerably lower, and these are considered early-onset PD (EOPD) patients. Most PD cases appear sporadic, but approximately 15% are familial, and some of the familial cases exhibit Mendelian inheritance. Genetic analysis of fami...

Early-onset drinking in Ireland: negative outcomes and behaviours.

Disease severity in familial cases of IBD.

BACKGROUND Phenotypic traits of familial IBD relative to sporadic cases are controversial, probably related to limited statistical power of published evidence. AIM To know if there are phenotype differences between familial and sporadic IBD, evaluating the prospective Spanish registry (ENEIDA) with 11,983 cases. METHODS 5783 patients (48.3%) had ulcerative colitis (UC) and 6200 (51.7%) Croh...

IBD LIVE Case Series--Case 3: Very Early-Onset Inflammatory Bowel Disease: When Genetic Testing Proves Beneficial.

LEARNING OBJECTIVES After completing this IBD LIVE-CME activity, physicians should be better able to: 1. Identify monogenic causes of early onset IBD. 2. Know when genetic testing might benefit the management of select IBD patients. 3. Be aware of potential clinical, endoscopic and histologic findings in early onset IBD. 4. Understand the pathophysiology and potential clinical course of IBD in ...